[目的]探讨启东市1972~2011年乳腺癌发病变化趋势,为乳腺癌预防控制提供依据。[方法]根据启东市1972~2011年癌症发病登记数据库,对乳腺癌发病率作年龄、时间趋势分析,计算指标包括粗发病率、中国人口标化率(中标率)、世界人口标化率(世标率)、35~64岁截缩率、0~74岁累积率、累积风险、变化百分比(PC)及年均变化百分比(APC)等。[结果]1972~2011年启东男女性乳腺癌共发病3452例,粗发病率为7.68/10万,占全部癌症发病的3.72%,位居癌症发病第6位。中标率和世标率分别为4.65/10万和6.13/10万;35~64岁截缩发病率为15.31/10万;0~74岁累积发病率为0.64%;乳腺癌发病的累积风险为0.64%。男女性乳腺癌发病性别比为1∶62.93。女性乳腺癌位居女性癌症发病的第4位,粗率、中标率和世标率分别为14.94/10万、9.00/10万和11.78/10万。女性乳腺癌的发病率随年龄的增加而升高,35~岁组进入增长期,50~岁组达到发病率高峰,为37.10/10万。40年间女性乳腺癌发病的粗率、中标率和世标率的变化百分比(PC)分别为269.74%、73.80%和81.48%,年均变化百分比(APC)分别为3.38%、1.21%和1.31%。各时期女性乳腺癌发病率显示25~34岁年龄组的升降趋势不明显,35~岁以后各年龄组的发病率均有上升趋势。年龄-出生队列方法分析女性乳腺癌,显示40~岁以后各年龄组的发病率均呈上升趋势。[结论]启东近40年来女性乳腺癌发病率有上升趋势,40岁以上的女性是乳腺癌防治的重点。 [Objective] To investigate the change trend of breast cancer in Qidong from 1972 to 2011, and provide evidence for prevention and control of breast cancer. [Methods] According to the database of cancer incidence in 1972 ~ 2011 in Qidong, the incidence of breast cancer was analyzed by age and time trend. The calculated indexes included crude incidence, Chinese population standardization rate (%), world population standardization rate World standard rate), 35-64 years of age shrinkage rate, 0-74 years old cumulative rate, cumulative risk, percentage change (PC) and average annual percentage change (APC). [Results] A total of 3452 cases of male and female breast cancer were found in Qidong from 1972 to 2011, with a crude incidence of 7.68 / 100 000, accounting for 3.72% of all cancers, ranking the 6th in the incidence of cancer. The winning rate and the world standard rate were 4.65 / 100,000 and 6.13 / 100,000 respectively; the incidence of truncation of 35-64 years old was 15.31 / 100,000; the cumulative incidence of 0-74 years was 0.64%; the cumulative risk of breast cancer was 0.64%. Male and female breast cancer incidence of sex ratio was 1:62.93. Female breast cancer ranks the 4th in the incidence of female cancers with a crude rate of 14.94 / lakh, a winning rate of 10% and a world standard rate of 9.00 / lakh and 11.78 / lakh respectively. The incidence of breast cancer in women increased with age, 35 to age group into the growth phase, 50 to the age group reached the peak incidence of 37.10 / 100,000. The percent change (PC) of the crude rate, the winning rate and the world standard rate of female breast cancer in 40 years were 269.74%, 73.80% and 81.48%, respectively, and the annual average percentage of change (APC) was 3.38%, 1.21% and 1.31% respectively. The prevalence of breast cancer in women in each period showed that the trend of increase and decrease in age group of 25 ~ 34 was not obvious, and the incidence of each age group increased after 35 ~ Age-birth cohort analysis of breast cancer in women shows a 40-year-old incidence of all age groups showed an upward trend. [Conclusion] The incidence of breast cancer in Qidong has a rising trend in the recent 40 years. Women over 40 years old are the focus of breast cancer prevention and treatment.