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为开发利用海带制碘工业联产品甘露醇,同时为防治冠状动脉粥样硬化疾患,发掘和研制老年人保健药物,自1970年以来,我们根据国外文献报道,经研制和动物实验,制成了新降血脂药——甘露醇烟酸酯。 众所周知,烟酸具有较强的扩散末梢血管作用,但服用后,常易出现颜面潮红灼热感或蚁走感,胃肠不适及发汗等副作用。 为了克服烟酸的副作用,国外有关专利介绍,曾采用D-甘露醇与烟酸进行酯化反应,合成甘露醇烟酸酯。并据国外文献报道,以鼠类用表面活性剂
For the development and utilization of kelp iodine industrial co-product mannitol, at the same time for the prevention and treatment of coronary atherosclerotic disease, to explore and develop the elderly health care, since 1970, we reported in foreign literature, research and animal experiments, made New hypolipidemic drugs - mannitol nicotinate. As we all know, niacin has a strong peripheral blood vessels proliferation, but after taking it, often prone to facial flushing sensation or ants feel away, gastrointestinal discomfort and sweating and other side effects. In order to overcome the side effects of nicotinic acid, foreign patents, have used D-mannitol esterification with niacin to synthesize mannitol nicotinate. According to foreign literature and reported to mice with surfactants