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目前已经认识到,动脉粥样硬化是一个由各种免疫细胞启动的炎症反应过程。参与其中的有固有免疫中的单核细胞、巨噬细胞,也有适应性免疫中的T细胞和B细胞,还包括其中的细胞因子。各种免疫细胞在动脉粥样硬化过程中起到的作用是不同的,有的会促进病变的发展,有的会抑制病变的发展。人类单核细胞中的CD14+CD16+细胞具有促炎作用,而有的CD14+CD16-细胞具有抑制炎症的作用;T细胞中的Th1和Th17细胞促进病变的发展,而Th2,CD4+CD25+调节性T细胞则作用相反。近年研究还发现,针对ox-LDL的抗体,对动脉粥样硬化的发生也具有保护作用。因此,深入研究免疫机制会对有效地的防治动脉粥样硬化有指导作用。
It has now been recognized that atherosclerosis is an inflammatory reaction initiated by a variety of immune cells. Involved in the innate immune monocytes, macrophages, but also adaptive immunity in T cells and B cells, but also include the cytokines. A variety of immune cells play a role in the process of atherosclerosis is different, and some will promote the development of lesions, and some will inhibit the development of lesions. CD14 + CD16 + cells in human monocytes have a proinflammatory effect, whereas some CD14 + CD16- cells have an inhibitory effect on inflammation; Th1 and Th17 cells in T cells promote the development of the disease, while Th2, CD4 + CD25 + regulatory T cells have the opposite effect. Recent studies also found that antibodies against ox-LDL also have a protective effect on the occurrence of atherosclerosis. Therefore, in-depth study of immune mechanisms will be effective in the prevention and treatment of atherosclerosis play a guiding role.