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目的探究臭氧联合椎旁神经阻滞治疗带状疱疹性神经痛的临床效果。方法选取龙岩市第一医院2012—2013年收治的150例带状疱疹后遗神经痛患者,按随机数字表法分为观察组和对照组,每组75例。两组患者均给予抗病毒和神经营养等常规治疗,对照组在此基础上给予椎旁神经阻滞治疗,观察组在对照组的基础上联合臭氧治疗。比较两组患者治疗前、治疗后1、2、3、4周疼痛视觉模拟评分(VAS)及临床疗效。结果两组患者治疗前及治疗后2周VAS评分比较,差异无统计学意义(P>0.05);两组治疗后3、4周VAS评分比较,差异有统计学意义(P<0.05)。观察组治愈38例,好转24例,减轻13例,无效0例,总有效率为82.7%;对照组治愈17例,好转21例,减轻32例,无效5例,总有效率为50.7%;观察组总有效率高于对照组,差异有统计学意义(P<0.01)。结论臭氧联合椎旁神经阻滞治疗带状疱疹性神经痛效果显著,可起到抗炎、镇痛、神经传导阻滞的综合作用。
Objective To investigate the clinical effects of ozone and paravertebral nerve block in the treatment of herpes zoster neuralgia. Methods 150 cases of postherpetic neuralgia patients admitted in the First Hospital of Longyan from 2012 to 2013 were randomly divided into observation group and control group, with 75 cases in each group. Two groups of patients were given routine antiviral and neurotrophic therapy, the control group on this basis to be given paravertebral nerve block treatment, the observation group in the control group based on the combination of ozone therapy. The pain visual analogue scale (VAS) and clinical efficacy of two groups before treatment, 1,2,3,4 weeks after treatment were compared. Results There was no significant difference in VAS score between the two groups before and 2 weeks after treatment (P> 0.05). There was significant difference in VAS score between the two groups at 3 and 4 weeks after treatment (P <0.05). In the observation group, 38 cases were cured, 24 cases improved, 13 cases reduced, 0 case ineffective, and the total effective rate was 82.7%. In the control group, 17 cases were cured, 21 cases improved, 32 cases reduced and 5 cases ineffective. The total effective rate was 50.7%. The total effective rate in observation group was higher than that in control group, the difference was statistically significant (P <0.01). Conclusion Ozone combined with paravertebral nerve block is effective in treating herpes zoster neuralgia and may play an integral role in anti-inflammatory, analgesic and nerve block.