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目的 :对比观察稳心颗粒与维拉帕米对室上性期前收缩的疗效及安全性。方法 :随机选取有明显临床症状的室上性期前收缩患者 112例。其中房性期前收缩 77例 ,交界性期前收缩 35例。随机分为 3组 ,稳心颗粒组 (n =4 0 ) :口服稳心颗粒 1包 (9g) ,tid ;维拉帕米组 (n =32 ) :口服维拉帕米 80mg ,tid ;稳心颗粒加维拉帕米组 (n =4 0 ) ,剂量与前两组相同 ,均 4周为 1疗程 ,观察用药前后临床症状、期前收缩次数及不良反应情况。结果 :稳心颗粒组有效率 72 .5 % ,维拉帕米组有效率 75 .0 % ,稳心颗粒加维拉帕米组有效率 95 .0 % ,服用稳心颗粒后患者心悸、胸闷症状明显少于服用维拉帕米者 (P <0 .0 5 )。结论 :稳心颗粒对室上性期前收缩的疗效与维拉帕米相似 ,但在临床症状的改善以及不良反应方面明显优于维拉帕米 ,与维拉帕米联合用药疗效增加 ,不良反应减少。
OBJECTIVE: To compare and observe the efficacy and safety of Wenxin Granules and verapamil on supraventricular premature contractions. Methods: One hundred and twelve patients with supraventricular premature contractions with obvious clinical symptoms were randomly selected. Among them, 77 cases were atrial contraction, 35 cases were borderline contractions. The rats were randomly divided into 3 groups: Wenxin granule group (n = 40): oral warfarin granule 1g (9g), tid; verapamil group (n = 32) Heart particles and verapamil group (n = 40), the same dose as the first two groups, were 4 weeks for a course of treatment before and after treatment to observe the clinical symptoms, the number of premature contractions and adverse reactions. Results: The effective rate was 72.5% in Wenxin Granule Group, 75.0% in Verapamil Group, 95.0% in Wenxin Granule plus Verapamil group, palpitations and chest tightness after taking Wenxin Granule The symptoms were significantly less than taking verapamil (P <0.05). Conclusion: Wenxin Granule has a similar curative effect to verapamil on supraventricular premature rupture, but is superior to verapamil in the improvement of clinical symptoms and adverse reactions. The combination therapy with verapamil has an increase in curative effect, Response decreased.