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目的 :探讨人胎蓝斑生长抑素 (SOM)免疫反应神经元的胚胎发育 ,为蓝斑脊髓移植挑选适宜胎龄提供形态学基础。方法 :用免疫组织化学法系统地观察人胎蓝斑生长抑素免疫反应神经元的发育。结果 :①蓝斑SOM神经元在胎龄 4mon已经出现。②蓝斑SOM神经元随胎龄增长逐渐增多 ,以 5mon时增加显著。③SOM神经元主要分布在蓝斑的背侧部。④SOM神经元开始出现时呈圆形或卵圆形 ,5mon～ 6mon时呈锥形和梭形 ,7mon～ 8mon时以梭形细胞为主。结论 :人胎蓝斑移植以 4mon胎龄作移植供体较适宜。
Objective: To explore the embryonic development of somatostatin (SOM) immunoreactive neurons in human fetal placenta and morphological basis for the selection of appropriate gestational age for placental spinal cord transplantation. Methods: The development of somatostatin immunoreactive neurons in human locus coeruleus was systematically observed by immunohistochemistry. Results: ① The blue spot SOM neurons in the gestational age 4mon have emerged. ② Locus SOM neurons increased gradually with gestational age, increased significantly at 5mon. ③ SOM neurons are mainly distributed in the dorsal part of the locust. ④ SOM neurons began to appear round or oval, 5mon ~ 6mon was tapered and fusiform, 7mon ~ 8mon-based spindle cells. Conclusion: Fetal locus coeruleus transplantation for 4mon gestational age for transplant donor more appropriate.