高血压是肾脏疾病中常有症状,可因此加重肾损伤。有效控制高血压是减缓肾脏疾病进展的重要环节。目前降压药物琳琅满目,现特就肾性高血压选用降压药物的有关问题简述于下。 1 影响血压的因素 影响血压因素虽多,但主要因素有:①中枢及交感神经系统;②胞外液容量;③肾素血管紧张素系统(RA);④前列腺素及激肽。其中后三个因素与肾脏有直接关联。要较好控制血压,当从这三个因素详加考虑。 1.1 胞外液容量:血压=心搏出量×外周血管阻力。从公式中看出,心搏量和/或外周血管阻力变化直接影响血压波动。而钠与液体容量均直接影响 Hypertension is a common symptom of kidney disease, which can exacerbate kidney damage. Effective control of hypertension is an important part of slowing the progression of kidney disease. At present, an array of antihypertensive drugs, are special about the use of antihypertensive drugs on renal hypertension related issues described below. 1 factors that affect blood pressure Although many factors affect blood pressure, but the main factors are: ① central and sympathetic nervous system; ② extracellular fluid volume; ③ renin angiotensin system (RA); ④ prostaglandin and kinin. The latter three factors are directly related to the kidneys. To better control blood pressure, when considering these three factors in detail. 1.1 Extracellular fluid volume: blood pressure = cardiac output × peripheral vascular resistance. It can be seen from the formula that changes in stroke volume and / or peripheral vascular resistance directly affect blood pressure fluctuations. The sodium and liquid capacity are directly affected