特异性移植免疫耐受是指在不使用免疫抑制剂的情况下,受者对供者抗原产生特异性免疫无反应,而同时又保持对除移植物以外的非己抗原的正常免疫应答能力。毫无疑问,诱导受者产生针对移植物的免疫耐受是彻底解决器官移植排斥反应问题的理想措施。在诸多耐受诱导研究中,诱导受者建立嵌合体似乎是最接近临床可能的方法。嵌合体是指 Specific immunosuppression refers to the fact that the recipient does not respond specifically to the donor antigen without the use of an immunosuppressive agent while maintaining the normal immune response to non-native antigens other than the graft. Undoubtedly, it is an ideal measure to completely solve the problem of organ transplant rejection by inducing recipients to produce immune tolerance against the graft. In many tolerance-inducing studies, inducing recipients to establish chimeras appears to be the closest clinical approach. Chimera means