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作者用DDD株小鼠进行体内和体外试验,观察吡喹酮对日本血吸虫卵的作用方式。每鼠接种60条血吸虫尾蚴,于7周后应用。吡喹酮悬浮于2%Cremophor水溶液中,每鼠经口给药100mg/kg,一日4次。对照组仅给Cremophor。每组均于给药的第2天及1、2、4和8周剖杀3鼠。用解剖镜观察在两块厚玻璃板间挤压后的整只鼠肝及肝门脉系血吸虫分布情况,发现100%血吸虫肝移。对照组肝移率分别为15.4、11.1、4.6、0和0%。每鼠计数肠壁内900只虫卵,按虫卵的类
The authors used DDD strains of mice in vitro and in vivo experiments to observe praziquantel on the role of Schistosoma japonicum eggs. Inoculated with 60 schistosome cercariae per mouse, after 7 weeks of application. Praziquantel was suspended in 2% Cremophor aqueous solution and each rat was orally administered 100 mg / kg orally 4 times a day. The control group only gave Cremophor. Each group was sacrificed on the second day of administration and 1, 2, 4 and 8 weeks. Using dissecting microscope to observe the distribution of Schistosoma japonicum and whole hepatic portal system schistosomiasis after squeezing between two thick glass plates, and found that 100% schistosomal liver transplantation. The control group liver metastasis rates were 15.4,11.1,4.6,0 and 0%. Each mouse counts 900 eggs in the intestinal wall, according to the class of eggs