AIM:To investigate electroacupunture(EA)at the acu-points of Stomach Meridian of Foot-Yangming(SMFY),Gallbladder Meridian of Foot-Yangming(SMFY)on gastricmucosal intestinal trefoil factor(ITF)gene expressiondetection in stress-induced rats with gastric mucosal le-sion,and to explore the regulatory mechanism and sig-nificance of EA-related gastric mucosal protective effect.METHODS:Forty rats were randomly divided into 4groups:Blank group,Model group,Model group+EAat acupoints of SMFY group(“SMFY group”),and Modelgroup+EA at acupoints of GMFY group(GMFY group).All rats(except blank group)were made model by waterimmersion and restraint stress(WRS).Then the gastricmucosa tissue in each rat was taken off after assessmentof gastric mucosal lesion index(GUI),and the expres-sion of ITF mRNA of the tissues was detected by reversetranscription-polymerase chain reaction(RT-PCR)method.RESULTS:Compared with Model group(54.3±1.34),the GUI value in SMFY group(31±2.21)decreasedsignificantly(P<0.01),so did that in GMFY group(39.8±1.62,P<0.05),meanwhile GUI value inSMFY group was significantly lower than in GMFYgroup(P<0.01).Compared with Model group(0.65±0.01),EA had a tendency to improve the expres-sion of gastric mucosal ITFmRNA gene:such tendencyexisted in GMFY group(0.66±0.01)but with no signfi-cant difference(P>0.05),in SMFY group(0.76±0.01)with an extremely obvious difference(P<0.01),further-more the expression in SMFY group was significantlyhigher than in GMFY group(P<0.01). AIM: To investigate electroacupunture (EA) at the acu-points of Stomach Meridian of Foot-Yangming (SMFY), Gallbladder Meridian of Foot-Yangming (SMFY) on gastric mucosal intestinal trefoil factor (ITF) gene expression detection in stress-induced rats with gastric mucosal le-sion, and to explore the regulatory mechanism and sig-nificance of EA-related gastric mucosal protective effect. METHODS: Forty rats were randomly divided into 4 groups: Blank group, Model group, Model group + EAat acupoints of SMFY group (“ SMFY group ”) and Modelgroup + EA at acupoints of GMFY group (GMFY group). All rats (except blank group) were made model by waterimmersion and restraint stress (WRS) .Then the gastric mucosa tissue in each rat was taken off after assessmentof gastric mucosal lesion index (GUI), and the expres-sion of ITF mRNA of the tissues was detected by reversetranscription-polymerase chain reaction (RT-PCR) method.RESULTS: Compared with Model group (54.3 ± 1.34), the GUI value in SMFY group (31 ± 2.21) decreasedsignantly (P <0. 01), so did that in GMFY group (39.8 ± 1.62, P <0.05), meanwhile GUI value in SMFY group was significantly lower than in GMFYgroup (P <0.01) .Compared with Model group (0.65 ± 0.01), EA had a tendency to improve the expres-sion of gastric mucosal ITF mRNA gene: such tendencyexisted in GMFY group (0.66 ± 0.01) but with no signfi-cant difference (P> 0.05), in SMFY group (0.76 ± 0.01) with an extremely obvious difference (P <0.01), further-more the expression in SMFY group was significantlyhigher than in GMFY group (P <0.01).