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用克山病病区低硒粮饲料喂养大鼠14周,探讨补硒(亚硒酸钠或硒酵母)对血小板聚集性和5—HT释放反应的影响。结果表明,补充两种硒制剂均能增加低硒大鼠血浆硒水平和血小板GSH—Px活性,降低ADP诱导的血小板聚集性和5—HT释放反应;两者的影响程度相似;补硒对血小板5—HT含量无显著影响。
Rats in low-selenium diet were fed with Keshan disease for 14 weeks to investigate the effect of selenium (sodium selenite or selenium yeast) on platelet aggregation and 5-HT release. The results showed that supplementation of two kinds of selenium preparations can increase the selenium level and selenium GSH-Px activity in selenium-induced selenium rats, reduce ADP-induced platelet aggregation and 5-HT release response; the extent of the impact of both similar; selenium on platelets 5-HT content had no significant effect.