胃肠道间质肿瘤(GIST)是腹腔最常见的间叶性肿瘤,来自于Cajal间质细胞或其前体细胞。大多数GISTs有c-kit癌基因的突变,c-kit(CD117)阳性被认为是诊断GIST的金标准,也是格列为治疗GIST的必要条件。近来研究发现PDGFRA基因突变作为另一个癌变机制可见于部分缺乏c-kit突变的GIST中 Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors in the abdominal cavity resulting from Cajal stromal cells or their precursor cells. Most GISTs have mutations in the c-kit oncogene, and positive for c-kit (CD117) is considered the gold standard for the diagnosis of GIST and is a requirement of GIST for the treatment of GIST. Recent studies have found that PDGFRA mutations as another mechanism of carcinogenesis can be found in GIST partially lacking c-kit mutations