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目的探讨PTEN、MMP9在妊娠合并子宫内膜异位症的表达及二者之间的相关性。方法采用免疫组织化学SP法检测30例正常子宫内膜组30例妊娠合并内异症组石蜡标本中PTEN及MMP9的表达情况。结果 PTEN在正常子宫内膜组表达高于妊娠合并卵巢内异症组,差异有显著性。MMP-9在妊娠合并卵巢内异症组表达高于正常子宫内膜组,差异有显著性。在妊娠合并卵巢内异症组PTEN及MMP-9表达呈负相关,PTEN及MMP-9的表达与卵巢内异症组分期相关,与囊肿大小无关。结论 PTEN、MMP-9异常表达可能参与了妊娠合并内异症的发生过程。
Objective To investigate the expression of PTEN and MMP9 in pregnancy complicated with endometriosis and the correlation between them. Methods Immunohistochemical SP method was used to detect the expression of PTEN and MMP9 in 30 cases of normal pregnancy with endometriosis group. Results The expression of PTEN in normal endometrium was higher than that in pregnancy with ovarian endometriosis, the difference was significant. The expression of MMP-9 in pregnancy with ovarian endometriosis was higher than that in normal endometrium, the difference was significant. The expression of PTEN and MMP-9 in pregnancy complicated with ovarian endometriosis group was negatively correlated. The expression of PTEN and MMP-9 was correlated with the stage of ovarian endometriosis, but not with the cyst size. Conclusion The abnormal expression of PTEN and MMP-9 may be involved in the pathogenesis of pregnancy complicated with endometriosis.