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目的:分析病毒性心肌炎(VMC)患儿血清白细胞介素-10(IL-10)、白细胞介素-8(IL-8)表达水平及临床意义,并探讨甘草酸二铵对病毒性心肌炎(VMC)的临床治疗效果。方法:采用双抗体夹心ELISA法对97例病毒性心肌炎患儿和68例正常儿童血清IL-10、IL-8含量进行测定,分析其临床意义。将97例VMC患者随机分为观察组和对照组,探讨甘草酸二铵对VMC的临床疗效。结果:VMC患儿血清IL-10、IL-8含量显著高于正常组,两组相比差异具有统计学意义(P<0.05)。治疗后观察组总有效率为92.16%,对照组为76.09%,观察组显著疗效显著优于对照组(χ2=9.669,P<0.05);其中观察组肌钙蛋白Ⅰ、心肌酶谱变化水平显著优于对照组(P<0.05)。结论:IL-10、IL-8在病毒性心肌炎的发生、发展中起到重要作用;甘草酸二铵可以有效提高VMC患儿的临床疗效,促进受损的心肌细胞快速修复,值得临床推广应用。
Objective: To investigate the expression of interleukin-10 (IL-10) and interleukin-8 (IL-8) in children with viral myocarditis (VMC) and to investigate the clinical significance of diammonium glycyrrhizinate on viral myocarditis VMC) clinical treatment effect. Methods: Serum levels of IL-10 and IL-8 in 97 children with viral myocarditis and 68 normal children were measured by double antibody sandwich ELISA. The clinical significance was analyzed. 97 patients with VMC were randomly divided into observation group and control group to investigate the clinical effect of diammonium glycyrrhizinate on VMC. Results: The serum levels of IL-10 and IL-8 in children with VMC were significantly higher than those in normal group. There was significant difference between the two groups (P <0.05). After treatment, the total effective rate was 92.16% in the observation group and 76.09% in the control group, and the significant effect in the observation group was significantly better than that in the control group (χ2 = 9.669, P <0.05). The changes in troponin I and myocardial enzymes in the observation group were significant Better than the control group (P <0.05). Conclusion: IL-10 and IL-8 play an important role in the pathogenesis and development of viral myocarditis. Diammonium glycyrrhizinate can effectively improve the clinical curative effect of VMC and promote the rapid repair of damaged cardiomyocytes, which is worthy of clinical application .