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Vc片是一种维生素类药物,美国及英国等药典对维生素类药物均未规定作溶出度检查,但该类药物溶出情况不清楚,为此,我们对Vc片的溶出度测定方法作了研究,并考察了不同地区、不同贮存期Vc片的溶出情况。1 仪器与药品1.1 仪器RC-3B型溶出度测定仪(天津大学无线电厂制造);UV-365紫外分光光度计(日本岛津)。1.2 药品Vc:由石家庄市第一制药厂提供;Vc片:由河北、内蒙、青海、宁夏四省七个药厂提供。2 实验条件的选择2.1 溶出度溶剂的选择本品在水中易溶,口服后由胃肠道吸收,故选用稀盐酸24ml加水至1000ml作为溶剂。2.2 测定波长的选择取Vc,加盐酸液(0.01mol/L)制成每1ml中含10μg的溶液,于340～220nm波长范围内
Vc tablets is a vitamin drugs, the United States and the United Kingdom and other pharmacopoeias for vitamins drugs are not prescribed for dissolution testing, but the dissolution of such drugs is not clear, therefore, we have Vc tablets dissolution assay was studied , And investigated the dissolution of Vc tablets in different regions and different storage periods. 1 Instruments and Pharmaceuticals 1.1 Instrument RC-3B Dissolution Tester (manufactured by Tianjin University Radio Factory); UV-365 UV spectrophotometer (Shimadzu). 1.2 Drug Vc: provided by Shijiazhuang No.1 Pharmaceutical Factory; Vc: provided by seven pharmaceutical factories in Hebei, Inner Mongolia, Qinghai and Ningxia provinces. 2 The choice of experimental conditions 2.1 Dissolution The choice of solvent This product is soluble in water, absorbed by the gastrointestinal tract after oral administration, so use dilute hydrochloric acid 24ml water to 1000ml as a solvent. 2.2 Determination of wavelength selection Take Vc, plus hydrochloric acid solution (0.01mol / L) per 1ml solution containing 10μg, in the 340 ~ 220nm wavelength range