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目的 研究精浆中的细胞因子的含量及其对男性生育能力的影响。方法 用ELISA法检测了 15例证明有生育能力的健康男性及 2 7例不育男性精浆中的IL 2 .IL 6、IL 8、TNF α、sIL 2R的含量 ,同时检测了精浆中的SOD、MDA及白细胞。结果 本组男性不育症 (非感染组 )患者精浆中的IL 6、IL 8、sIL 2R水平与有生育能力的男性相比有差异 ,感染组精浆中的IL 2 .IL 6、IL 8、TNF α、sIL 2R的含量与生育组比有明显的差异 (P <0 .0 1)。结论 本研究提示生殖道感染时精浆中的细胞因子与男性不育有密切的相关
Objective To study the content of cytokines in seminal plasma and its effect on male fertility. Methods The contents of IL 2, IL 6, IL 8, TNF α and sIL 2R in 15 cases of fertile male and 27 cases of sterile male seminal plasma were detected by ELISA. SOD, MDA and leukocytes. Results The levels of IL 6, IL 8 and sIL 2R in seminal plasma of male infertility patients (non-infected group) in this group were significantly different from those of fertile men. IL 2, IL 6, IL 8, TNFα, sIL 2R content and fertility group were significantly different (P <0.01). Conclusions This study suggests that cytokines in seminal plasma are closely related to male infertility during reproductive tract infections