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目的对氨基苷类抗生素引起的不良反应进行分析,以期找到合理使用氨基苷类抗生素的方法。方法对2006年1月～2010年6月期间在我院使用氨基苷类抗生素后发生不良反应的82例患者的临床资料进行回顾性研究。结果在这82例患者中,出现听力受损者有43例,出现肾功能受损者有26例,出现过敏反应者有12例,出现神经功能受损者有1例。在出现听力受损的43例患者中,有35例患者为6岁以下的儿童,其余8例患者均为孕妇。在出现肾功能受损的26例患者中,有17例患者的年龄大于55岁,其余9例患者均有肾功能不全的病史。结论 6岁以下的儿童和孕妇应慎用或禁用氨基苷类抗生素,老年人或有肾功能不全者在使用氨基苷类抗生素期间应密切监测肾功能。
Objective To analyze the adverse reactions caused by aminoglycoside antibiotics in order to find a reasonable way to use aminoglycoside antibiotics. Methods The clinical data of 82 patients who had adverse reactions after using aminoglycoside antibiotics in our hospital from January 2006 to June 2010 were retrospectively studied. Results Of these 82 patients, 43 were impaired hearing, 26 had impaired renal function, 12 had anaphylactic reaction, and 1 had impaired neurological function. Of the 43 patients with impaired hearing, 35 were children under 6 years of age and the remaining 8 were pregnant women. Of the 26 patients with impaired renal function, 17 were older than 55 and the remaining 9 had a history of renal insufficiency. Conclusions Aminoside antibiotics should be used with caution or disabled in children under 6 years of age and pregnant women, and renal function should be closely monitored during the use of aminoglycosides in the elderly or in patients with renal insufficiency.