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目的探讨血清成纤维细胞生长因子-21在2型糖尿病(T2DM)患者中的表达水平及相关性分析。方法选取T2DM组(初诊2型糖尿病)48例、Con组(健康组)50例进行各项指标对比研究。采用ELISA法检测各组血清FGF-21水平情况,分析血清FGF21水平与临床体征指数的关系。结果 T2DM组患者血清中的FGF21、TC、TG、LDL-C、FFA、BMI、WHR、FBG、FINS、HOMA-IR明显高于Con组(P<0.05);T2DM组、Con组血清FGF-21水平均与TG、FFA、BMI、HOMA-IR水平呈正相关(P<0.05)。结论初诊为T2DM患者血清中FGF-21明显升高,并且与血清TG水平及胰岛素抵抗等参数具有相关性,可能与糖脂代谢紊乱有关,可作为预测糖尿病风险指标之一。
Objective To investigate the expression of serum fibroblast growth factor-21 in patients with type 2 diabetes mellitus (T2DM) and its correlation analysis. Methods 48 cases of T2DM group (newly diagnosed type 2 diabetes mellitus) and 50 cases of Con group (healthy group) were selected for comparison of various indexes. The levels of serum FGF-21 in each group were detected by ELISA, and the relationship between serum FGF21 level and clinical signs index was analyzed. Results Serum FGF21, TC, TG, LDL-C, FFA, BMI, WHR, FBG, FINS and HOMA-IR in T2DM group were significantly higher than those in Con group (P < The levels were positively correlated with TG, FFA, BMI and HOMA-IR (P <0.05). Conclusions The serum level of FGF-21 in patients with newly diagnosed T2DM is significantly higher than that in patients with newly diagnosed T2DM. It is correlated with serum TG levels and insulin resistance, which may be related to the disorders of glucose and lipid metabolism and may be used as a predictor of diabetes mellitus.