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目的探讨真核翻译起始因子-5A2在乳腺癌组织中的表达的临床意义。方法收集我院2008年1月至2010年12月有完整存档蜡块资料的50例乳腺癌蜡块并对其进行免疫组织化学染色,检测EIF-5A2在乳腺癌中的表达,并且对EIF-5A2的表达情况与疾病的病理生物学特点进行分析,以判断其对预后的意义。结果 EIF-5A2阳性表达86%,EIF-5A2在肿瘤中的表达与肿瘤临床分期、淋巴结转移、与雌激素受体(ER)状态呈负相关。结论 EIF-5A2在乳腺癌中有高表达,与临床分期密切相关。
Objective To investigate the clinical significance of eukaryotic translation initiation factor-5A2 expression in breast cancer. Methods Fifty cases of breast cancer paraffin blocks from January 2008 to December 2010 in our hospital were collected and immunohistochemically stained to detect the expression of EIF-5A2 in breast cancer. EIF- 5A2 expression and pathological and biological characteristics of the disease were analyzed to determine the significance of its prognosis. Results The positive expression of EIF-5A2 was 86%. The expression of EIF-5A2 in the tumor was negatively correlated with the clinical stage, lymph node metastasis and estrogen receptor (ER) status. Conclusion EIF-5A2 is highly expressed in breast cancer and is closely related to clinical stage.