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目的:研究黄秋葵胶囊的抗疲劳作用及机制,为临床应用提供实验科学依据。方法:分别给小鼠灌胃给予黄秋葵胶囊内容物0.15、0.30、0.90 g/kg剂量,采用负重游泳实验方法观察黄秋葵胶囊的抗疲劳作用,并测定小鼠血清尿素氮、肝糖原、血乳酸含量,对黄秋葵胶囊抗疲劳作用机制进行初步探索。结果:负重游泳实验中,各剂量组小鼠负重游泳时间显著长于对照组(P<0.05);各剂量组小鼠血清尿素氮及血乳酸水平显著低于对照组(P<0.05)。结论:黄秋葵胶囊对小鼠具有显著的抗疲劳作用,且其机制与改善小鼠葡萄糖、蛋白质代谢分解、调节小鼠血清尿素氮及血乳酸水平有关。
Objective: To study the anti-fatigue effect and mechanism of okra capsule, and to provide experimental scientific basis for clinical application. Methods: The mice were gavaged with 0.15, 0.30, 0.90 g / kg of okra capsule. The antifatigue effect of okra capsule was observed by the method of load-bearing swimming test. The levels of serum urea nitrogen, hepatic glycogen, Content, the antifatigue mechanism of okra capsule preliminary exploration. Results: The swimming time of mice in each dose group was significantly longer than that of the control group (P <0.05). The levels of serum urea nitrogen and blood lactate in each dose group were significantly lower than those in the control group (P <0.05). Conclusion: Okra capsule has a significant anti-fatigue effect on mice, and its mechanism is related to the improvement of mice glucose and protein metabolism, and the regulation of serum urea nitrogen and blood lactate level in mice.