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近十年来关于淀粉样变性发病机制的免疫学说由于许多新的因素的发现而发生十分重要的变化。这些因素是:淀粉样蛋白的组蛋白具有抗原特异性;它是由特殊的细胞系——一种具有巨噬细胞性质的成淀粉样蛋白细胞所合成;这种蛋白存在可溶性前体物质,该物质是Ig和免疫调节蛋白轻链的衍生物,等等。现在已经肯定,获得性淀粉样变性的病因都是相同的,即抗原过度刺激造成机体免疫内环境稳定失调所致。它的发生与原发疾病的类别无关(副蛋白血症性造血组织增生例外),与实验中所用淀粉样蛋白原的种类亦无关。
The immunology of the pathogenesis of amyloidosis in the past decade has been a very significant change due to the discovery of many new factors. These factors are: Amyloid histone is antigen specific; it is synthesized by a special cell line, an amyloidogenic cell with macrophage properties; this protein has a soluble precursor substance which Substances are derivatives of Ig and immunomodulatory light chains, and the like. It has now been affirmed that the etiology of acquired amyloidosis is the same, that the over-stimulation of the antigen causes the stable immune imbalance in the body. Its occurrence has nothing to do with the primary disease category (paraproteinemia hematopoietic proliferation exception), and the type of amyloid used in the experiment also has nothing to do.