我们选择了1986～1988年广州市红十字会医院等内科住院的108例胃、十二指肠溃疡患者,并在同一医院选择了117例对照进行研究。应用logistic回归方法进行单因素和多因素分析。多因素分析结果表明:吸烟,家族溃疡病史,喜欢甜食,经常熬夜与胃、十二指肠溃疡有关。还表现出明显的剂量反应关系。重度吸烟的为3.16(1.10～11.22),中度吸烟为2.64(1.30～5.37),轻度吸烟为1.75(0.71～4.32)。 We selected 108 cases of gastric and duodenal ulcers hospitalized in the department of internal medicine such as Guangzhou Red Cross Hospital from 1986 to 1988, and selected 117 controls in the same hospital for study. Univariate and multivariate analyses were performed using logistic regression methods. The results of multivariate analysis showed that: smoking, family history of ulcers, like sweets, often stays up late with the stomach, duodenal ulcer. Also showed a significant dose-response relationship. Severe smoking was 3.16 (1.10 to 11.22), moderate smoking was 2.64 (1.30 to 5.37), and mild smoking was 1.75 (0.71 to 4.32).