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结肠直肠癌(colorectal carcinoma,CRC)是我国常见恶性肿瘤之一,其发病率呈上升趋势,尤其在经济发展较快的地区。目前的治疗方式是手术治疗,术前新辅助治疗以及术后放、化疗。但是,20%的CRC病人在确诊时已发现转移~[1],只能接受姑息性手术治疗,且仅有12%的生存率~[2];而且50%的病人手术后,因微卫星转移而复发~[3]。新开发的化疗药物不
Colorectal carcinoma (CRC) is one of the common malignant tumors in our country. The incidence of colorectal carcinoma (CRC) is on the increase, especially in areas with rapid economic development. The current treatment is surgical treatment, preoperative neoadjuvant and postoperative radiotherapy and chemotherapy. However, 20% of CRC patients at the time of diagnosis have been found to have metastasized to [1], receive only palliative surgery and have only a 12% survival rate [2]; and because 50% of patients undergo microsatellite Metastasis and recurrence ~ [3]. Newly developed chemotherapeutic drugs do not