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对象和方法本组研究对象为远端溃疡性结肠炎及直肠炎患者28例。均给予丁地去炎松(budesonide)2mg,每晚睡前保留灌肠(溶于100ml溶剂中),疗程为4周。检查其药物动力学,对清晨血浆皮质醇的影响及治疗效果。结果丁地去炎松显著降低内镜下病变记分,从2.5±0.5分降至0.9±0.8分(P<0.0001),4.5分为重度溃疡的临界值。组织学改变记分亦从3.7±0.7分降至2.6±1.3分,效果非常显著(P<0.002),5分为重度溃疡的临界
Subjects and methods of this group of patients with distal ulcerative colitis and proctitis in 28 patients. All patients were given budesonide 2mg. The enema was preserved every night before going to bed (dissolved in 100ml of solvent) for 4 weeks. Check its pharmacokinetics, the impact of early morning plasma cortisol and treatment. Results Ding to triamcinolone significantly reduced endoscopic lesions score, from 2.5 ± 0.5 points to 0.9 ± 0.8 points (P <0.0001), 4.5 points for the critical value of severe ulcers. Histological change score also dropped from 3.7 ± 0.7 to 2.6 ± 1.3, the effect is very significant (P <0.002), 5 points for the critical of severe ulcers