[Objective] The research aimed to discuss the effects of Grifola frondosa polysaccharide on immune function in mice. [Method] The 30 healthy Kunming mice were randomly divided into three groups of 10 each: control group, low-dose group and high-dose group. Low-dose group and high-dose group mice were respectively fed with low or high doses of Grifola frondosa polysaccharides (300 or 400 mg/kg body weight). Control group mice were fed with distilled water. Mice of each group were allowed to feed on their dose once a day for 15 successive days to study the effect of Grifola frondosa polysaccharide on immune organ weight and blood biochemical indexes.[Result] The results showed that the thymus index in low-dose group was significantly lower than that in control group (P<0.05), and spleen index in low-dose group and high-dose group was very significantly and significantly higher than that in control group (P<0.01, P<0.05), respectively. The serum total protein and the serum globulin levels in low-dose group were significantly or very significantly higher than that in control group (P<0.05, P<0.01). The serum total cholesterols level in low-dose group was significantly lower than that in control group (P<0.05). The serum IgG in low-dose group was significantly higher than that in control group (P<0.05). [Conclusion] The results indicated that the Grifola frondosa polysaccharides in low-dose group could increase the spleen weight and serum antibody content and reduce total cholesterol level, which had a significant effect on enhancing immune function and reducing blood lipids in mice. [Objective] The research aimed to discuss the effects of Grifola frondosa polysaccharide on immune function in mice. [Method] The 30 healthy Kunming mice were randomly divided into three groups of 10 each: control group, low-dose group and high-dose group . Low-dose group and high-dose group mice were respectively fed with low or high doses of Grifola frondosa polysaccharides (300 or 400 mg / kg body weight). Control group mice were fed with distilled water. Mice of each group were allowed to feed on their dose once a day for 15 successive days to study the effect of Grifola frondosa polysaccharide on immune organ weight and blood biochemical indexes. [Result] The results showed that the thymus index in low-dose group was significantly lower than that in control (P <0.05), and spleen index in low-dose group and high-dose group was very significantly and significantly higher than that in control group (P <0.01, P <0.05), respectively. The serum total protein and the serum globulin levels The serum total cholesterols level in low-dose group was significantly lower than that in control group (P <0.05). The results indicated that the Grifola frondosa polysaccharides in low-dose group could increase the spleen weight and serum antibody content and reduce total (P <0.05) cholesterol level, which had a significant effect on enhancing immune function and reducing blood lipids in mice.