在临床上肝素广泛应用于防治血栓栓塞性疾病、弥漫性血管内凝血的早期治疗及体外抗凝。研究显示 ,肝素除具有抗凝作用外 ,还具有多种生物活性 ,其中 ,肝素对炎症过程的影响正日益受到关注。本文将从肝素与肥大细胞的关系、肝素抑制白细胞粘附于血管内皮及其随后向组织的迁移等方面来讨论肝素对炎症的影响及其作用机制 ,并探讨肝素的抗炎作用应用于临床的前景 In clinical heparin is widely used in the prevention and treatment of thromboembolic diseases, diffuse early treatment of intravascular coagulation and anticoagulation in vitro. Studies have shown that in addition to heparin anticoagulant effect, but also has a variety of biological activity, of which the impact of heparin on the inflammatory process is receiving increasing attention. This article will discuss the relationship between heparin and mast cells, heparin inhibition of leukocyte adhesion to the vascular endothelium and its subsequent migration to the tissue to discuss the impact of heparin on inflammation and its mechanism of action, and explore the anti-inflammatory effect of heparin used in clinical prospect