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目的评价雌激素受体1(ESR1)rs9340799(Xbal)、rs2234693(PvuⅡ)基因多态性与青少年特发性脊柱侧凸(AIS)的相关性。方法计算机检索Pub Med、万方医学网、中国生物医学文献数据库(CBM)、中国学术期刊全文数据库(CNKI)、维普全文数据库等,按照纳入标准收集ESR1基因多态性与青少年特发性脊柱侧凸相关性的病例对照研究数据,末次检索时间为2015年7月23日。采用Stata 12.0软件进行Meta分析,对研究数据的OR值进行合并,并对发表偏倚进行评估。结果根据纳入和剔除标准,共4篇文献符合要求,有关ESR1 rs9340799文献4篇,有关rs2234693文献3篇。ESR1 rs9340799基因多态性与AIS关联性研究中,等位基因模型(G vs.A)、显性模型(GG+AG vs.AA)、隐性模型(GG vs.AG+AA)的OR值分别为1.08(0.83~1.21)、1.06(0.91~1.24)、1.08(0.63~1.83),差异均无统计学意义。ESR1 rs2234693基因多态性与AIS关联性研究中,等位基因模型(C vs.T)、显性模型(CC+TC vs.TT)、隐性模型(CC vs.TC+TT)的OR值分别为1.08(0.92~1.26)、1.07(0.85~1.35)、1.14(0.85~1.54),差异均无统计学意义。结论结果表明,目前相关研究尚不能证明ESR1rs9340799及rs2234693基因多态性与AIS有关。
Objective To evaluate the association between estrogen receptor 1 (ESR1) rs9340799 (Xbal), rs2234693 (PvuII) gene polymorphism and adolescent idiopathic scoliosis (AIS). Methods PubMed, Wanfang Medical Network, CBM, CNKI and VIP databases were searched by computer. The ESR1 gene polymorphism and adolescent idiopathic scoliosis Convex correlation case-control study data, the last search time for July 23, Meta-analysis was performed using Stata 12.0 software, the OR values for the study data were combined, and publication bias was assessed. Results According to inclusion and exclusion criteria, a total of 4 articles met the requirements, 4 articles on ESR1 rs9340799 and 3 articles on rs2234693. In the association study between ESR1 rs9340799 gene polymorphism and AIS, the odds ratio (G vs. A), the dominant model (GG + AG vs. AA) and the recessive model (GG vs. AG + AA) Respectively, 1.08 (0.83-1.21), 1.06 (0.91-1.24) and 1.08 (0.63-1.83), respectively, with no significant difference. The correlation between ESR1 rs2234693 polymorphism and AIS was statistically significant (P <0.05). The OR of allele model (C vs. T), dominant model (CC + TC vs. TT) and recessive model (CC vs.TC + TT) Respectively, 1.08 (0.92-1.26), 1.07 (0.85-1.35), 1.14 (0.85-1.54), the difference was not statistically significant. Conclusion The results show that the current research has not yet proved that ESR1 rs9340799 and rs2234693 gene polymorphisms and AIS.