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[目的]探讨唯美生放射免疫治疗联合射频消融治疗原发性肺癌的疗效及血液学毒性。[方法]选取2009年8月到2011年2月原发性肺癌患者13例,均经6个疗程以上化疗,临床评估认为继续化疗不能获益者。患者在CT引导下进行肿瘤局部射频消融治疗,术中唯美生瘤内注射,剂量按29.6MBq/kg给予。[结果]治疗后2d,唯美生全身放射免疫显像,所有患者病灶部位均有不同程度唯美生浓聚。治疗后1个月,白细胞明显下降(t=0.1887,P=0.0142),血小板有轻度下降(t=0.8334,P=0.3872)。治疗后3个月,胸部CT示,CR3例、PR2例、SD4例、PD4例,总缓解率(CR+PR)38.46%(5/13),疾病控制率(CR+PR+SD)69.23%(9/13)。[结论]唯美生放射免疫治疗联合射频消融治疗原发性肺癌疗效较好,毒副反应较轻。
[Objective] To investigate the curative effect and hematological toxicity of Aesthetic Radiotherapy combined with radio-frequency ablation on primary lung cancer. [Methods] Thirteen patients with primary lung cancer were selected from August 2009 to February 2011. All of them were treated by more than 6 courses of chemotherapy. Clinical evaluation indicated that they could not benefit from continuing chemotherapy. Patients under CT-guided local tumor radiofrequency ablation treatment, intraoperative tumor injection only beautiful, the dose given by 29.6MBq / kg. [Results] 2 days after treatment, only the United States Health Radiation immune imaging, all patients have different levels of focus on the concentration of Aesthetic Health. One month after treatment, leukocytes decreased significantly (t = 0.1887, P = 0.0142) and platelets decreased slightly (t = 0.8334, P = 0.3872). Three months after treatment, chest CT, CR3, PR2, SD4 and PD were 38.46% (5/13) and 69.23% (CR + PR + SD) (9/13). [Conclusion] Weimeisheng radioimmunotherapy combined with radiofrequency ablation for the treatment of primary lung cancer has good curative effect and mild side effects.