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目的：研究人乳头瘤病毒（humanpapillomavirus，HPV）与宫颈癌的病因关系。方法：采用聚合酶链反应（PolymeraseChainReaction，PCR）检测不同宫颈粘液标本137份，其中正常宫颈37例、宫颈炎53例、宫颈癌47例。结果：上述三种标本中，HPV－16DNA的检出率分别为18．9％、43．4％和72．3％。宫颈癌标本中HPV－16检出率显著高于宫颈正常组（P＜0．01），宫颈癌组与宫颈炎组中HPV－16检出率比较，两者差异无显著意义（P＞0．05）。结论：宫颈癌发病与HPV感染有密切关系。
Objective: To study the etiology of human papillomavirus (HPV) and cervical cancer. Methods: 137 cases of different cervical mucus specimens were detected by polymerase chain reaction (PCR), including 37 normal cervix, 53 cervicitis and 47 cervical cancer. Results: The detection rates of HPV-16 DNA were 18.9%, 43.4% and 72.3% in the above three specimens respectively. The detection rate of HPV-16 in cervical cancer specimens was significantly higher than that in normal cervical tissues (P <0.01). There was no significant difference in HPV-16 detection rate between cervical cancer and cervicitis (P> 0 .05). Conclusion: The incidence of cervical cancer and HPV infection are closely related.