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目的 探讨间歇白细胞去除法对系统性红斑狼疮等风湿性疾病的治疗效果。方法 2 0例患儿 (其中系统性红斑狼疮 8例、过敏性紫癜肾炎 5例、幼年型类风湿关节炎 3例、混合性结缔组织病 2例 ,皮肌炎、硬皮病各 1例 )在常规治疗疗效不明显的情况下 ,加用间歇性白细胞去除法治疗 ,每次 10 0～ 2 0 0mL ,每周 1～ 2次 ,病情稳定后改为 1～ 2个月 1次。结果 2 0例中 18例治疗后临床症状和体征均逐步明显好转 ,各项实验室指标同步改善 ,保证了激素的安全减量。间歇白细胞去除法前后血象改变表明 ,除血小板有轻度降低外 ,白细胞、红细胞、血红蛋白均无明显改变。结论 间歇白细胞去除法治疗儿童风湿性疾病 ,有良好的效果
Objective To investigate the therapeutic effect of intermittent leukocyte depletion on rheumatic diseases such as systemic lupus erythematosus. Methods 20 cases of children (including 8 cases of systemic lupus erythematosus, 5 cases of allergic purpura nephritis, juvenile rheumatoid arthritis in 3 cases, mixed connective tissue disease in 2 cases, dermatomyositis, scleroderma in 1 case) In the case of conventional treatment is not obvious, plus intermittent leukapheresis treatment, each 10 ~ 2 0 0mL, 1 to 2 times a week, stable condition changed to 1 to 2 months 1 time. Results Among the 20 cases, the clinical symptoms and signs of 18 cases improved obviously gradually. All the laboratory indexes improved synchronously, which guaranteed the safe reduction of hormones. Intermittent leukocyte removal before and after changes in blood shows that, in addition to a slight decrease in platelets, white blood cells, red blood cells, hemoglobin were no significant changes. Conclusion Intermittent leukocyte depletion in children with rheumatic diseases, with good results