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据美国《Science News》1993年144卷第20期报道 胰岛素依赖型糖尿病患者大约35％的人有患糖尿病肾病的危险。卡托普利——一种ACE抑制剂,对胰岛素依赖型糖尿病肾病患者具有保护肾脏功能的作用。研究者们调查了409名均在30岁以前患糖尿病的病人,年龄为18～49岁,其病史至少10年以上,并伴有糖尿病肾病。通过尿蛋白测定和评估血清肌酐酸浓度以表明肾脏的损害。在这项双盲试验里,207名患者服用卡托普利,每日三次每次25mg,而另外202名患者接受安慰剂。共有301名患者按计划完成了这项调查。结果发现,在糖尿病组中,卡
According to the “Science News” 1993 Volume 144, Volume 20 reported that about 35% of insulin-dependent diabetes patients are at risk of diabetic nephropathy. Captopril, an ACE inhibitor, has a protective effect on kidney function in patients with insulin-dependent diabetic nephropathy. The researchers investigated 409 patients with diabetes before the age of 30, aged 18 to 49 years and had a history of at least 10 years with diabetic nephropathy. Serum creatinine concentrations were measured and assessed by urinary protein to indicate kidney damage. In this double-blind trial, 207 patients took captopril, 25 mg three times daily, and another 202 received placebo. A total of 301 patients completed the survey as planned. The results showed that in the diabetic group, the card