细菌可诱导巨噬细胞凋亡,主要通过其毒力因子如内毒素、外毒素、超抗原和侵袭素等,使细菌逃避宿主的第一道免疫防线;凋亡的巨噬细胞通过分泌炎症细胞因子诱发炎症反应,是导致感染严格局限性的重要因素。研究细菌与巨噬细胞凋亡的关系对感染性疾病的治疗和预防具有重要意义。 Bacteria can induce apoptosis of macrophages, making bacteria escape the host’s first immune defense mainly through its virulence factors such as endotoxins, exotoxins, superantigens and invasive elements. Apoptotic macrophages are secreted by inflammatory cells Factor-induced inflammation is an important factor that leads to severe limitations of infection. Studying the relationship between bacterial and macrophage apoptosis is of great significance for the treatment and prevention of infectious diseases.