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对国产和进口辛伐他汀片的调脂疗效和安全性行随机对照研究。结果显示:国产和进口产品均能有效降低血胆固醇(TC),总有效率各为95.00%和94.74%(P>0.05);降低血甘油三脂(TG)的总有效率各为72.72%和66.66%(P>0.05);降低动脉硬化指数(TC-HDL-C/HDL-C)的总有效率各为85.00%和89.74%(P>0.05)。两产品均能升高高密度脂蛋白(HDL-C及HDL2-C)和降低载脂蛋白(APO)B100、CⅡ、CⅢ。以上调脂疗效及不良不反应相似,提示国产品可替代进口品
A randomized controlled study on lipid-lowering efficacy and safety of domestic and imported simvastatin tablets. The results showed that both domestic and imported products can effectively reduce blood cholesterol (TC), the total effective rate was 95.00% and 94.74% (P> 0.05), and the total triglyceride (TG) The total effective rates of lowering atherosclerosis index (TC-HDL-C / HDL-C) were respectively 85.00% and 89.74% (P> 0.05). Both products increased high density lipoprotein (HDL-C and HDL2-C) and decreased apolipoproteins (APO) B100, CII and CIII. The above lipid-lowering efficacy and adverse reactions are similar, suggesting that domestic products can replace imported products