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目的:研究排风藤(Solanum cathayanum)提取物及其某些单体化合物对肝脏的保护作用。方法:在体以CCl4诱导小鼠急性肝损伤模型,测定各组肝损伤小鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)活性及总胆红素(TBILI)含量;体外实验采用小鼠离体肝细胞原代培养,并建立CCl4诱导肝细胞坏死性损伤模型,检测其对ALT活性的影响。结果:排风藤能显著降低小鼠血清中升高的ALT和AST水平,显著降低小鼠血清的总胆红素(TBILI)含量,同时显著降低离体培养中染毒肝细胞中的ALT水平。结论:排风藤对小鼠化学性肝损伤具有显著的保护作用。
Objective: To study the protective effects of Solanum cathayanum extract and some of its monomeric compounds on liver. Methods: The acute liver injury model induced by CCl4 in mice was used to measure the levels of ALT, AST and TBILI in mice with liver injury. Mice Primary culture of isolated hepatocytes was performed. CCl4-induced hepatocyte necrosis injury model was established and its effect on ALT activity was examined. Results: Tamarix ramulus could significantly reduce the elevated levels of ALT and AST in the serum of mice and significantly reduce the content of total bilirubin (TBILI) in the serum of mice and significantly reduce the level of ALT in the exposed hepatocytes in vitro . Conclusion: Exfoliating vine has a significant protective effect on chemical liver injury in mice.