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以不同的受体选择性视黄素处理乳腺癌细胞，通过荧光显微术、ＴｄＴ测定和细胞生长测定，分析视黄素诱导的癌细胞凋亡及其对癌细胞生长抑制的相互关系；将受体ＲＡＲα基因转染乳腺癌ＭＢ－２３１细胞，发现受体转染与细胞凋亡诱导有关；ＲＡＲ和ＲＸＲ受体选择性视黄素联合使用，对诱导癌细胞凋亡和抑制癌细胞生长具有加强作用．结果证实，视黄素能够诱导乳腺癌细胞的细胞凋亡，并与抑制癌细胞的恶性生长相一致，这可能是视黄素抗癌作用的机制之一．
Breast cancer cells were treated with different receptor-selective retinoids. Fluorescence microscopy, TdT assay and cell growth assay were used to analyze the relationship between retinoic acid-induced apoptosis of cancer cells and the growth inhibition of cancer cells. The receptor RARα gene was transfected into breast cancer cell line MB-231 and found that the receptor transfection was related to the induction of apoptosis. The combined use of RAR and RXR receptor-selective retinol had the effects on inducing cancer cell apoptosis and inhibiting the growth of cancer cells Strengthen the role. The results confirmed that retinoic acid can induce apoptosis of breast cancer cells, and inhibit the malignant growth of cancer cells consistent, which may be retinoic acid one of the mechanisms of anti-cancer.