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目的:探讨前列腺未分化肉瘤伴软骨化生的临床表现和病理特点,进一步明确其所属类别。方法:分析2009年2月收治的1例前列腺未分化肉瘤伴软骨化生患者的临床资料,对该例手术切除的肿瘤组织行常规HE及免疫组化染色,光镜下观察其组织结构和免疫组化表达,并结合文献复习其临床表现。结果:病理诊断:灰白色前列腺肿物,镜下见其含有软骨肉瘤和未分化肉瘤成分。免疫组化染色:波形蛋白(+),局部CD117(±)。平滑肌肌动蛋白、结蛋白、肌红蛋白、CD34、细胞角蛋白CK7、CK8均为(-)。术后2个月发现肿瘤转移,4个月后患者死亡。结论:本例患者为前列腺未分化肉瘤伴软骨化生,该例肿瘤是一种恶性程度较高的侵袭性肿瘤,非常罕见,需经病理检查和免疫组化来确诊。
Objective: To investigate the clinical manifestations and pathological features of undifferentiated sarcoma with cartilage metaplasia, and to further clarify its classification. Methods: The clinical data of 1 patient with undifferentiated prostate sarcoma and cartilage metaplasia who were treated in February 2009 were analyzed. The tumor tissues were excised routinely by immunohistochemistry and HE staining. The histology and immunostaining were observed under light microscope Histochemical expression, combined with the literature review of its clinical manifestations. Results: pathological diagnosis: gray-white prostatic tumor, microscopic see it contains chondrosarcoma and undifferentiated sarcoma components. Immunohistochemical staining: vimentin (+), local CD117 (±). Smooth muscle actin, desmin, myoglobin, CD34, cytokeratin CK7, CK8 are (-). Tumor metastasis was found 2 months after the operation and died after 4 months. Conclusion: This patient is undifferentiated sarcoma of the prostate with cartilage metaplasia. This case is a highly malignant tumor which is very rare and confirmed by pathological examination and immunohistochemistry.