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目的观察七叶皂苷钠联合甘露醇治疗脑出血的临床疗效。方法选择北京市仁和医院2012年10月—2013年11月收治的脑出血患者113例,随机分为对照组56例和治疗组57例。两组患者均给予常规治疗,对照组患者在常规治疗基础上给予20%甘露醇125 ml静脉滴注,4次/d;治疗组患者在对照组治疗基础上给予七叶皂苷钠20mg+0.9%氯化钠溶液250 ml静脉滴注,1次/d。两组患者均连续治疗14 d。观察两组患者的临床疗效,治疗前后神经功能缺损评分、血肿量及治疗期间不良反应情况。结果治疗组患者总有效率为96.49%,高于对照组的71.43%(P<0.05)。两组患者治疗前神经功能缺损评分、血肿量比较,差异均无统计学意义(P<0.05);治疗组患者治疗后神经功能缺损评分低于对照组,血肿量小于对照组(P<0.05)。对照组患者治疗期间不良反应发生率为7.14%,与治疗组的8.77%比较,差异无统计学意义(P>0.05)。结论七叶皂苷钠联合甘露醇治疗脑出血的临床疗效确切,有助于改善患者神经功能。
Objective To observe the clinical efficacy of sodium aescinate combined with mannitol in the treatment of cerebral hemorrhage. Methods 113 patients with cerebral hemorrhage admitted to Beijing Renhe Hospital from October 2012 to November 2013 were randomly divided into control group (56 cases) and treatment group (57 cases). Patients in the control group were given intravenous drip of 20% mannitol 125 ml on the basis of routine treatment four times a day. Patients in the treatment group were given sodium aescinate 20 mg and 0.9% Sodium chloride solution 250 ml intravenously, 1 time / d. Two groups of patients were treated for 14 days. The clinical efficacy, neurological deficit scores, hematoma volume and adverse reactions during and after treatment were observed. Results The total effective rate of the treatment group was 96.49%, which was higher than 71.43% of the control group (P <0.05). There was no significant difference between the two groups in the score of neurological deficit and the amount of hematoma before treatment (P <0.05). The score of neurological deficit in the treatment group was lower than that in the control group, and the amount of hematoma was smaller than that in the control group (P <0.05) . The incidence of adverse reactions in the control group was 7.14% during the treatment period, which was not significantly different from the treatment group (8.77%) (P> 0.05). Conclusion The clinical efficacy of sodium aescinate combined with mannitol in the treatment of cerebral hemorrhage is definite and helps to improve the neurological function of patients.