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枣庄市精神病院王继玲报道:患者杨××,男,35岁,H3500。诊断精神分裂症住院,以氯氮平治疗,初50毫克/日,第五天氯氮平增至150毫克/日时,病人诉面部有痒感。第六天,颈以上皮肤红、面部浮肿并有丘疹,至第七天面部皮肤有糜烂和渗出,全身其他部位无皮疹,无其它不适感,不发烧,停用氯氮平,给10％葡萄糖加氟美松15毫克,维生素C1克作静脉滴注,局部用脱敏药膏涂擦,历3天,浮肿减轻,经5天治疗,颈、面部皮损消失。
Zijiazhuang mental hospital reported Wang Jiling: Yang × ×, male, 35 years old, H3500. Diagnosis of schizophrenia hospitalized with clozapine treatment, the first 50 mg / day, the fifth day clozapine increased to 150 mg / day, the patient complained of facial itching. The sixth day, neck and above the skin red, facial edema and papules, to the seventh day facial skin erosion and exudation, the rest of the body no rash, no other discomfort, no fever, stop clozapine, to 10% Glucose plus chloromethasone 15 mg, Vitamin C1 grams for intravenous infusion, topical desensitization cream rubbed, calendar 3 days, edema relief, after 5 days of treatment, neck, facial lesions disappear.