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为研究妊娠期大鼠接触锰对母体及子代发育的影响，对妊娠大鼠，于孕第一天开始，每隔一天，腹腔内注射氯化锰水溶液。４个染锰组的染锰剂量分别为每次３．７５ｍｇ／ｋｇ、７．５ｍｇ／ｋｇ、１５ｍｇ／ｋｇ和３０ｍｇ／ｋｇ。自然分娩，观察母仔的生长发育情况。结果发现：①３０ｍｇ／ｋｇ的染锰剂量对孕鼠有明显的毒性，表现为体重下降，妊娠中止；②１５ｍｇ／ｋｇ染锰组仔鼠的出生体重及头臀长均显著低于对照组；③１个月龄时，３．７５ｍｇ／ｋｇ和７．５ｍｇ／ｋｇ染锰组仔鼠的体重和头臀长均大于对照组，而１５ｍｇ／ｋｇ染锰组则仍低于正常对照组；④２～３个月龄时，１５ｍｇ／ｋｇ染锰组仔鼠体重低于对照组，其余染锰组与对照组之间，未见有显著性差异。提示：孕期锰接触，超过一定量时，对母体及子代的生长发育均可产生明显的影响。
To study the effects of exposure to manganese on gestational maternal and offspring development in pregnant rats, on the first day of pregnancy, every other day, intraperitoneal injections of aqueous manganese chloride solution. The manganese dosing amounts for the 4 manganese-dosed groups were 3.75 mg / kg, 7.5 mg / kg, 15 mg / kg and 30 mg / kg each, respectively. Natural childbirth, observing the growth and development of the mother and child. The results showed that: (1) The manganese dose of 30 mg / kg had obvious toxicity to pregnant rats, showing weight loss and pregnancy termination; (2) The birth weight and head-hip length of offspring of 15 mg / kg Mn-Mn group were significantly lower than that of the control group At month old, body weight and head-hip length of pups in 3.75mg / kg and 7.5mg / kg pigs were higher than those in control group, while those in 15mg / kg manganese group were still lower than those in normal control group. At the age of 15 months, the weight of the pups in the 15 mg / kg Mn-Mn group was lower than that in the control group, and there was no significant difference between the other Mn-Mn groups and the control group. Tip: pregnant manganese exposure, more than a certain amount, the growth of maternal and offspring can have a significant impact.