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【目的】研究宫内TORCH感染对新生儿神经行为发育的影响,为进一步干预提供依据。【方法】选择胎龄37～42周,脐血或外周血检查TORCH系列抗体一项或多项IgM(+),母亲在产前筛查或产时监测TORCH系列抗体一项或多项同种病原体IgM(+)的新生儿作为感染组,同期检查母亲及新生儿脐血或外周血TORCH感染均为阴性的100例新生儿为对照组,两组新生儿均在出生后48～72h、12～14d、26～28d测查NBNA评分。【结果】新生儿风疹病毒、巨细胞病毒、疱疹病毒、弓形虫感染率统计学比较差异有统计学意义(P<0.05),其中巨细胞病毒感染率最高为1.48%,弓形虫感染率最低为0.12%;各时间段风疹病毒和巨细胞病毒感染组新生儿NBNA评分均低于对照组(P<0.05),弓形虫和疱疹病毒感染组新生儿NBNA评分与对照组差异无统计学意义(P>0.05),各感染组间NBNA评分差异无统计学意义(P>0.05)。同一感染组,新生儿NBNA评分在三个时间段比较差异均有统计学意义(P<0.05)。【结论】宫内TORCH感染会影响新生儿行为神经的发育。
【Objective】 To study the effect of intrauterine TORCH infection on the neurobehavioral development in neonates and provide basis for further intervention. 【Methods】 One or more IgM (+) TORCH antibodies were detected in cord blood or peripheral blood from 37 to 42 weeks gestation. Mothers were monitored for one or more isolates of TORCH antibodies during prenatal screening or during labor. Neonates with pathogen IgM (+) as the infection group, 100 newborns with negative TORCH infection in both mother and newborn during the same period as controls, 48 to 72 hours after birth in both groups ~ 14d, 26 ~ 28d NBNA score. 【Results】 The infection rates of neonatal rubella virus, cytomegalovirus, herpesvirus and toxoplasm were statistically significant difference (P <0.05), the highest infection rate of cytomegalovirus was 1.48% and the lowest infection rate of toxoplasma was 0.12% respectively. NBNA scores in neonates with rubella virus and cytomegalovirus infection were significantly lower than those in control group at each time point (P <0.05), but NBNA scores in neonates with Toxoplasma gondii and herpes simplex virus infection were not significantly different from those in control group (P > 0.05). There was no significant difference in NBNA score between different infection groups (P> 0.05). In the same infection group, neonatal NBNA score was significantly different in three time periods (P <0.05). 【Conclusion】 Intrauterine TORCH infection can affect the development of newborn behavioral neurons.