【摘 要】
:
目的 了解我国肉鸡养殖屠宰加工环节大肠埃希菌的耐药状况,并探究新冠疫情期间消毒剂的使用对其耐药性的影响.方法 针对我国河南、山东和辽宁三省肉鸡养殖场和屠宰厂中分离获得的722株大肠埃希菌,采用微量肉汤稀释法对12类27种抗菌药物开展耐药性检测,并以山东分离株为例分析新冠疫情发生前后菌株耐药性变化.结果 722株养殖和屠宰加工环节大肠埃希菌分离株中,96.0%为耐药株,6类9种药物的耐药率在75%以上,最高为氨苄西林(AMP)达88.1%,多西环素(DOX)等8种药物的中介率超过10%,多重耐药株占全部耐药
【机 构】
:
国家食品安全风险评估中心国家卫生健康委员会食品安全风险评估重点实验室,北京 100021
论文部分内容阅读
目的 了解我国肉鸡养殖屠宰加工环节大肠埃希菌的耐药状况,并探究新冠疫情期间消毒剂的使用对其耐药性的影响.方法 针对我国河南、山东和辽宁三省肉鸡养殖场和屠宰厂中分离获得的722株大肠埃希菌,采用微量肉汤稀释法对12类27种抗菌药物开展耐药性检测,并以山东分离株为例分析新冠疫情发生前后菌株耐药性变化.结果 722株养殖和屠宰加工环节大肠埃希菌分离株中,96.0%为耐药株,6类9种药物的耐药率在75%以上,最高为氨苄西林(AMP)达88.1%,多西环素(DOX)等8种药物的中介率超过10%,多重耐药株占全部耐药菌株的94.7%,共有517种耐药谱,耐受10类和9类药物的菌株数量最多,118株菌可同时耐受11类药物,其中2株可对24种药物耐药.新冠肺炎疫情后山东省大肠埃希菌分离株对DOX、多粘菌素B(PB)以及氨苄西林-舒巴坦(AMS)/阿莫西林-克拉维酸(AMC)的耐药性有明显提升.结论 我国禽类养殖和屠宰加工环节大肠埃希菌分离株的耐药性整体处于较高水平,多重耐药严重,可能与相关药物在食品链条上游的长期普遍使用有关.新冠疫情期间,肉鸡养殖和屠宰加工环节实施的消毒措施,可能对大肠埃希菌分离株对部分抗菌药物耐药水平的提升有一定影响,应从预防角度入手开展持续主动监测,以充分评估消毒剂使用对食品链条中致病菌分离株耐药性提升的风险.
其他文献
Dear Editor,rnSocial anxiety disorder (SAD) is one of the most common psychiatric disorders.It is characterized by intense and persistent fear of one or more social situations in which one is exposed to possible scrutiny by others[1].The lifetime prevalen
Rosai-Dorfman 病(Rosai-Dorfman disease,RDD)又名窦性组织细胞增生伴巨大淋巴细胞病,是一种特发性、非肿瘤性、淋巴增生性疾病,最常累及颈部淋巴结.根据病变的累及范围,RDD可分为淋巴结、结外和混合受累3种类型.发生于脑实质内的RDD鲜有报道.笔者现对上海儿童医学中心小儿神经外科收治1例儿童脑实质型RDD患儿的诊治经过回顾分析,并结合文献复习,对该疾病的临床特点进行总结.
Mechanistic target of rapamycin (mTOR) sig-naling governs important physiological and pathological processes key to cellular life.Loss of mTOR negative regulators and subsequent over-activation of mTOR sig-naling are major causes underlying epileptic ence
重复经颅磁刺激(repetitive transcranial magnetic stimu-lation,rTMS)是非侵入性物理治疗技术,是目前抑郁症治疗的常用方法之一,2008年被美国FDA批准用于抑郁症临床治疗[1-2].精准靶点rTMS是对传统rTMS方案的优化,广义的精准是在精准医学(precise medicine)层面,狭义的精准是指物理层面上的靶点精准定位(precise loca-tion).精准医学层面上的rTMS,是依据抑郁症患者临床症状亚型、客观脑影像特征等生物亚型,对患者rTM
Dear Editors,rnAutism spectrum disorder is a highly heritable neurodevel-opmental disorder and is often associated with sleep disorders and dysregulation of the circadian rhythm[1,2].Whether neural circuits governing the circadian rhythm are causally asso
The 2021 Nobel Prize in Physiology or Medicine was awarded to two sensory neurobiologists and pain researchers,David Julius at the University of California in San Francisco and Ardem Patapoutian at Scripps Research in San Diego,for their discoveries of th
Parkinson\'s disease (PD),the second most common neurodegenerative disease,is clinically charac-terized by both motor and non-motor symptoms.Although overall great achievements have been made in elucidating the etiology and pathogenesis of PD,the exact
Dear Editor,rnOur auditory organ,the cochlea,resides in the ventral portion of the inner ear,and its sensory epithelium,the organ of Corti,contains hair cells (HCs) and supporting cells (SCs),which are both descendants of the same progenitors.HCs are pron
食品安全检验方法标准是食品安全标准体系中重要组成部分,文章主要阐述了食品安全检验方法标准的内涵,介绍了理化、微生物、毒理学、寄生虫方法标准和基础类检验方法标准现状及其存在的问题.针对如何提升检验方法标准体系的适用性,加强检验方法标准技术管理能力,加强检验方法标准研制的基础研究和国际交流合作,构建全方位、多层次、立体化的检验方法标准体系提出建设性意见.
目的:采用超高效液相色谱-四极杆-静电场轨道阱高分辨质谱法(UPLC-Q-Orbitrap-MS)对小承气汤中的化学成分进行快速识别和鉴定.方法:采用CORTECS T3色谱柱(2.1 mm×150 mm,1.6 μm),以甲醇(A)-0.1%甲酸水溶液(B)作为流动相进行梯度洗脱(0~5 min,3%~21%A;5~20 min,21%~36%A;20~32 min,36%~50%A;32~42 min,50%~62%A;42~50 min,62%~85%A;50~60 min,85%~95%A),流速