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目的:比较山莨菪碱(654-2)与酮咯酸氨丁三醇(尼松)对肾绞痛的止痛疗效和不良反应。方法:将2012年5月-2013年5月在福建省宁德市闽东医院急诊外科确诊的421例肾绞痛患者随机分为研究组(n=211)和对照组(n=210),分别应用654-2注射液静脉滴注和尼松注射液肌肉注射治疗,比较两组对肾绞痛的止痛效果及不良反应。结果:研究组与对照组的止痛有效率分别为92.42%和93.33%,差异无统计学意义(P>0.05),而研究组的不良反应较尼松组少且轻微。结论:654-2与尼松对肾绞痛的止痛效率均在90%以上,且无明显差异,但654-2的副作用少且轻;654-2治疗肾绞痛较尼松更安全,建议临床推广应用。
Objective: To compare the analgesic effects and side effects of anisodamine (654-2) and ketorolac tromethamine (nisin) on renal colic. Methods: A total of 421 patients with renal colic who were diagnosed as emergency surgery in Mindong Hospital, Ningde City, Fujian Province from May 2012 to May 2013 were randomly divided into study group (n = 211) and control group (n = 210) Application of intravenous infusion of 654-2 injection and intramuscular injection of Nissin injection treatment, analgesic effect and adverse reactions of the two groups on renal colic. Results: The analgesic efficiencies of study group and control group were 92.42% and 93.33%, respectively, with no significant difference (P> 0.05). The adverse reactions of study group were less and less than those of nisin group. CONCLUSIONS: Both analgesic efficiencies of 654-2 and nisin on renal colic are over 90% with no significant difference, but the side effects of 654-2 are less and less severe; 654-2 is more safer to treat renal colic than nisin Clinical application.