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缺氧诱导因子-1α(HIF-1α)是细胞缺氧适应与应答调节的关键因子。通过调控其下游基因的表达在肿瘤发生、发展中起重要作用,同时其表达又与肿瘤的预后和对放化疗的敏感性密切相关。本文就HIF-1α在口腔肿瘤中的研究进展作一综述。
Hypoxia-inducible factor-1α (HIF-1α) is a key factor in the regulation of cellular hypoxia adaptation and response. It plays an important role in tumorigenesis and development by regulating the expression of its downstream genes, and its expression is closely related to the prognosis of the tumor and the sensitivity to radiotherapy and chemotherapy. This article reviews the research progress of HIF-1α in oral tumors.