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目的:检测口腔鳞癌(OSCC)中血管内皮生长因子-C(VEGF-C)的表达,以探讨VEGF-C与OSCC淋巴转移的关系及其临床意义。方法:应用免疫组织化学染色(S-P法)检测40例OSCC组织及14例正常口腔黏膜组织中VEGF-C的表达情况。结果:45.0%的OSCC组织中可见VEGF-C表达,在正常口腔黏膜中无表达;22例伴淋巴结转移的OSCC组织中,68.2%有VEGF-C表达,18例不伴有淋巴结转移者,16.7%有VEGF-C表达,两组之间差异有统计学意义(P<0.01);16.7%的Ⅰ～Ⅱ期OSCC有VEGF-C表达,57.1%的Ⅲ～Ⅳ期OSCC有VEGF-C表达,两者之间差异有统计学意义(P<0.05);与肿瘤的部位、年龄及性别无关(P>0.05)。结论:VEGF-C在OSCC组织中表达明显上调,并与淋巴管生成、颈淋巴结转移及TNM分期等临床病理生物学行为有关,提示VEGF-C可能在OSCC的生长及转移中起重要作用。
Objective: To investigate the expression of vascular endothelial growth factor-C (VEGF-C) in oral squamous cell carcinoma (OSCC) and to explore the relationship between VEGF-C and lymphatic metastasis in OSCC and its clinical significance. Methods: The expression of VEGF-C in 40 OSCC tissues and 14 normal oral mucosa tissues was detected by immunohistochemical staining (S-P method). Results: The expression of VEGF-C was found in 45.0% of OSCC tissues and no expression in normal oral mucosa. Of the 22 OSCC tissues with lymph node metastasis, 68.2% had VEGF-C expression, 18 were not associated with lymph node metastasis, 16.7 (P <0.01). VEGF-C expression was found in 16.7% of OSCCs with stage ¢ ñ to ¢ ó OSIS, while VEGF-C was expressed in 57.1% of OSCCs with stage ¢ ó to ¢ ô OSCC. There was significant difference between the two groups The difference between the two groups was statistically significant (P <0.05), but not related to tumor location, age and gender (P> 0.05). Conclusion: The expression of VEGF-C is up-regulated in OSCC tissues, which is related to the clinicopathological behaviors such as lymphangiogenesis, cervical lymph node metastasis and TNM staging, suggesting that VEGF-C may play an important role in the growth and metastasis of OSCC.