视网膜母细胞瘤是一种好发生于婴幼儿的疾病,其发病率约为1:16000～34000不等。根据我院以前统计的病例,均为散发性者,现将我院遇到的一家姐弟四人均患视网膜母细胞瘤的病例报告如下; 王××(先证者)男3个月于1985年9月26日来本院就诊。患儿父母说其生后两个月右眼瞳孔有白色反光,夜间在灯下较明显。近几天发现其眼向外斜,瞳孔内白光更加明显。检查:患儿发育正常,两眼等大,右眼外斜约15°。角膜及晶体透明,瞳孔大小正 Retinoblastoma is a good disease occurs in infants and young children, the incidence of about 1: 16000 ~ 34000 range. According to our hospital before the statistical cases, are sporadic, now our hospital encountered a sister and four cases of retinoblastoma are as follows; Wang XX (proband) male for 3 months in 1985 September 26, to our hospital. Parents say their parents have two months after birth pupil white reflective, night under the lights more obvious. In recent days found that its outward-looking oblique pupil white light more obvious. Check: children with normal development, two large eyes, right eye outside the oblique about 15 °. Cornea and crystal transparent, pupil size is positive