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越来越多的研究发现3羟-3甲戊二酰-辅酶A(HMG-CoA)还原酶抑制剂——他汀具有免疫调节作用。目前证明他汀类在多发性硬化(MS)发病的多个免疫环节发挥治疗作用,如抑制抗原递呈,改变Th1/Th2细胞平衡,以及影响MHC-Ⅱ分子、粘附分子、细胞因子、趋化因子受体及基质金属蛋白酶(MMPs)等蛋白分子的表达,可能有助于他汀类在MS等中枢神经系统自身免疫性疾病的应用的进一步研究。
More and more studies have found that 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor - statin has an immunomodulatory effect. Statins have been shown to exert therapeutic effects on multiple immune processes in the pathogenesis of multiple sclerosis (MS), such as inhibiting antigen presentation, altering the balance of Th1 / Th2 cells, and influencing MHC-II molecules, adhesion molecules, cytokines, chemotaxis Factor receptors and matrix metalloproteinases (MMPs) and other protein molecules may contribute to the statins in the CN and other central nervous system autoimmune diseases for further study.