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微环境调控是促进创面修复和皮肤再生的关键技术。近年来，系列调控微环境和细胞行为的新型生物活性材料得以研发，显示出高效诱导创面修复和皮肤附件再生的能力。本文就相关新型生物活性材料的研究进展及其作用机制进行总结。“,”The modulation of microenvironment is a key technology towards promoting wound repair and skin regeneration. In recent years, a series of new bioactive materials that modulate the microenvironment and cell behaviors have been developed, demonstrating highly efficient capability of inducing wound repair and skin appendage regeneration. This article summarizes the research development of related new bioactive materials and their mechanisms of action.