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目的分析合并乙肝病毒感染的初诊2型糖尿病患者胰岛素泵短期治疗的效果。方法回顾性分析曾接受胰岛素泵(CSⅡ)强化治疗2周的初诊2型糖尿病患者的临床特点,包括乙肝病毒感染组26例(HBsAg阳性,乙肝组),与乙肝组HbA_1c及年龄、性别、BMI相匹配的对照组52例(HBsAg阴性)。结果与对照组比较,乙肝组空腹血糖相对较低[(9.38±1.09)mmol/L vs (10.46±1.14)mmol/L],餐后2小时血糖较高[(19.61±3.92)mmol/L vs (16.78±3.15)mmol/L],乙肝组胰岛素、HOMA-β也高于对照组(P<0.05)。乙肝组在3月、6月、12月、24月及36月血糖维持达标率均高于对照组(P<0.05)。结论胰岛素泵治疗后2周停用降糖药物的第3,6,12,24,36周随访血糖达标缓解率乙肝组高于对照组。乙肝病毒感染可能对2型糖尿病患者糖代谢存在影响。
Objective To analyze the short-term effect of insulin pump in patients with newly diagnosed type 2 diabetes mellitus complicated with hepatitis B virus infection. Methods The clinical features of newly diagnosed type 2 diabetic patients who had undergone CS Ⅱ intensive treatment for 2 weeks were retrospectively analyzed. Among them, 26 cases were positive for hepatitis B virus (HBsAg positive, hepatitis B), HbA_1c and age, sex, BMI The matched controls were 52 (HBsAg negative). Results Compared with the control group, fasting blood glucose in hepatitis B group was relatively lower (9.38 ± 1.09 mmol / L vs 10.46 ± 1.14 mmol / L), and blood glucose was higher at 2 hours after meal (19.61 ± 3.92 mmol / L vs (16.78 ± 3.15) mmol / L]. The insulin and HOMA-β in hepatitis B group were also higher than those in control group (P <0.05). The blood glucose maintenance rate in hepatitis B group was higher in March, June, December, 24 and 36 months than that in control group (P <0.05). Conclusions The 3, 6, 12, 24 and 36-week follow-up remission rate of blood glucose after 2 weeks of insulin pump treatment is lower than that of the control group. Hepatitis B virus infection may have an impact on glycometabolism in patients with type 2 diabetes.