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本文研究了左旋多巴(L-Dopa)对实验性癫痫——听源性发作(AS)和电休克引起的惊厥(MES)的影响。给听源性发作敏感大鼠分别腹腔注射不同剂量的 L-Dopa盐水混悬液(L-Dopa 200 mg+多巴外周脱羧酶抑制剂——Benserazide 50mg)。实验结果证明,对大鼠听源性发作有对抗作用,其 ED_(50)=13.8(7.1～25.3)mg/kg。给小鼠腹腔注射不同剂量的 L-Dopa,30分钟后进行实验,对 MES 也有明显对抗作用,其 ED_(50)=100(67.1～149.7)mg/kg。L-Dopa 上述作用,主要与其增加动物脑内多巴胺(DA)含量有关,而与其增加脑内的去甲肾上腺素(NE)的含量关系不大。因为 L-Dopa 抗大鼠 AS 的作用强度与其增加脑内 DA 含量相平行,而与 NE 含量的增加无平行关系;脑室内注射 DA(60μg/kg)或 NE(60μg/kg),DA 的作用比 NE 强;以去水吗啡(6mg/kg)激动 DA-受体,亦有抗大鼠 AS 的作用(P<0.01)。相反,以氟哌啶(0.5mg/kg)阻断 DA-受体,则能对抗L-Dopa 的上述作用。给大鼠腹腔注射 DA-β羟化酶抑制剂——双硫醒(250mg/kg),使大鼠脑内 NE 含
This article investigates the effects of L-Dopa on experimental epilepsy-auditory seizures (AS) and electrical shock-induced convulsions (MES). Sensitized rats with auditory seizure were intraperitoneally injected with different doses of L-Dopa saline suspension (L-Dopa 200 mg + dopa peripheral decarboxylase inhibitor - Benserazide 50 mg). Experimental results show that the antagonism of auditory seizures in rats, the ED50 (13.8 (7.1 ~ 25.3) mg / kg. The mice were injected intraperitoneally with different dosages of L-Dopa. After 30 minutes, the mice were challenged with MES. ED50 = 100 (67.1-149.7) mg / kg. The above effects of L-Dopa are mainly related to the increase of dopamine (DA) content in the brain of the rats, but not to the increased content of norepinephrine (NE) in the brain. Because the intensity of L-Dopa anti-rat AS was in parallel with its increase in brain DA content, it was not paralleled by the increase of NE content. The intracerebroventricular injection of DA (60μg / kg) or NE (60μg / kg) It was stronger than NE; DA-receptor was also induced by desmethylmorphine (6mg / kg) and anti-rat AS (P <0.01). In contrast, blockade of DA-receptors with haloperidol (0.5 mg / kg) counteracted the above effects of L-Dopa. Rats were injected intraperitoneally DA-β-hydroxylase inhibitor - bisulfate (250mg / kg), so that the rat brain NE