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目的:探讨细辛脑羟丙基-β-环糊精溶液剂鼻腔给药脑内释药的可行性。方法:采用家兔静脉注射细辛脑羟丙基-β-环糊精溶液剂与家兔鼻腔灌流细辛脑羟丙基-β-环糊精溶液剂相比较,探求细辛脑鼻腔给药后药物在脑内释放的可行性通路。结果:鼻腔灌流方式血液中细辛脑质量浓度与嗅脑、大脑、筛鼻甲内的细辛脑的量,均高于静脉给药方式。结论:细辛脑羟丙基-β-环糊精溶液剂经过筛鼻甲进入脑部这一通路过程中,药物的吸收量方面,静脉给药要小于鼻腔灌流,故细辛脑鼻腔给药脑内释药具有实践之可行性。
Objective: To investigate the feasibility of nasal administration of Asarum hydroxypropyl-β-cyclodextrin solution intranasally. Methods: Compared with the nasal solution of Asarum hydroxypropyl-β-cyclodextrin in rabbits intravenously injected with Asarum hydroxypropyl-β-cyclodextrin solution Feasible pathway for the release of drugs in the brain. Results: The concentration of Asarum in the blood of nasal perfusion method and the amount of Asarum in the olfactory brain, brain and ethmoid turbinate were all higher than those in the intravenous administration. Conclusion: Asarone hydroxypropyl-β-cyclodextrin solution through the sieve turbinate into the brain during this pathway, the absorption of drugs, intravenous administration is less than nasal perfusion, so asarone nasal administration of brain Internal release medicine with practical feasibility.